PUBLICATIONS
Optimal Neuromuscular Performance Requires Motor Neuron Phosphagen Kinases.
, Fily Y, Macleod GT. bioRxiv. 2025. Listen: Podcast
Bichromatic exon-reporters reveal voltage-gated Ca2+-channel splice-isoform diversity across Drosophila neurons in vivo.
Feghhi T, Hernandez RX, Mahneva O, Oliva CD, Macleod GT. bioRxiv. 2024. Listen: Podcast
Ultrastructural analysis reveals mitochondrial placement independent of synapse placement in fine caliber C. elegans neurons.
Riboul DV, Crill S, Oliva CD, Restifo MG, Joseph R, Joseph K, Nguyen KC, Hall DH, Fily Y, Macleod GT. J Comp Neurol. 2024 Dec;532(12):e70002. Listen: Podcast
Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals.
Justs KA, Sempertegui S, Riboul DV, Oliva CD, Durbin RJ, Crill S, Stawarski M, Su C, Renden RB, Fily Y, Macleod GT. J Physiol. 2023 Dec;601(24):5705-5732. Listen: Podcast
Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.
He K, Han Y, Li X, Hernandez RX, Riboul DV, Feghhi T, Justs KA, Mahneva O, Perry S, Macleod GT, Dickman D. J Neurosci. 2023 Jun;43(25):4598-4611.
Presynaptic Mitochondrial Volume and Packing Density Scale with Presynaptic Power Demand.
Justs KA, Lu Z, Chouhan AK, Borycz JA, Lu Z, Meinertzhagen IA, Macleod GT. J Neurosci. 2022 Feb;42(6):954-967. Listen: Podcast
Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft.
Feghhi T, Hernandez RX, Stawarski M, Thomas CI, Kamasawa N, Lau AWC, Macleod GT. Biophys J. 2021 Dec;120(24):5575-5591. Listen: Podcast
Neto-a Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction.
Han TH, Vicidomini R, Ramos CI, Wang Q, Nguyen P, Jarnik M, Lee CH, Stawarski M, Hernandez RX, Macleod GT, Serpe M. Cell Rep. 2020 Jul;32(1):107866.
Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.
Stawarski M, Hernandez RX, Feghhi T, Borycz JA, Lu Z, Agarwal AB, Reihl KD, Tavora R, Lau AWC, Meinertzhagen IA, Renden R, Macleod GT. J Neurosci. 2020 Feb;40(8):1611-1624. Listen: Podcast
Endogenous Tagging Reveals Differential Regulation of Ca2+ Channels at Single Active Zones during Presynaptic Homeostatic Potentiation and Depression.
Gratz SJ, Goel P, Bruckner JJ, Hernandez RX, Khateeb K, Macleod GT, Dickman D, O’Connor-Giles KM. J Neurosci. 2019 Mar;39(13):2416-2429.
The application of ‘kisser’ probes for resolving the distribution and microenvironment of membrane proteins in situ.
Stawarski M, Justs KA, Hernandez RX, Macleod GT. J Neurogenet. 2018 Sep;32(3):236-245.
The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.
Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ. Cell Rep. 2017 Dec;21(13):3794-3806.
Na+ /H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals.
Rossano AJ, Kato A, Minard KI, Romero MF, Macleod GT. J Physiol. 2017 Feb;595(3):805-824.
High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design.
Lu Z, Chouhan AK, Borycz JA, Lu Z, Rossano AJ, Brain KL, Zhou Y, Meinertzhagen IA, Macleod GT. Curr Biol. 2016 Oct;26(19):2562-2571.
A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K. Neuron. 2014 Nov;84(4):764-77.
The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.
Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H. PLoS One. 2014 Jun;9(6):e100834.
Expression of multiple transgenes from a single construct using viral 2A peptides in Drosophila.
Daniels RW, Rossano AJ, Macleod GT, Ganetzky B. PLoS One. 2014 Jun;9(6):e100637.
The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.
Grygoruk A, Chen A, Martin CA, Lawal HO, Fei H, Gutierrez G, Biedermann T, Najibi R, Hadi R, Chouhan AK, Murphy NP, Schweizer FE, Macleod GT, Maidment NT, Krantz DE. J Neurosci. 2014 May;34(20):6924-37.
Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice.
Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, McArdle A, Brooks SV. FASEB J. 2014 Apr;28(4):1666-81.
Mitochondrial free Ca²? levels and their effects on energy metabolism in Drosophila motor nerve terminals.
Ivannikov MV, Macleod GT. Biophys J. 2013 Jun;104(11):2353-61.
Genetically encoded pH-indicators reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo.
Rossano AJ, Chouhan AK, Macleod GT. J Physiol. 2013 Apr;591(7):1691-706.
Forward-filling of dextran-conjugated indicators for calcium imaging at the Drosophila larval neuromuscular junction.
Macleod GT. Cold Spring Harb Protoc. 2012 Jul;2012(7):791-6.
Topical application of indicators for calcium imaging at the Drosophila larval neuromuscular junction.
Macleod GT. Cold Spring Harb Protoc. 2012 Jul;2012(7):786-90.
Calcium imaging at the Drosophila larval neuromuscular junction.
Macleod GT. Cold Spring Harb Protoc. 2012 Jul;2012(7):758-66.
Imaging and analysis of nonratiometric calcium indicators at the Drosophila larval neuromuscular junction.
Macleod GT. Cold Spring Harb Protoc. 2012 Jul;2012(7):802-9.
Direct injection of indicators for calcium imaging at the Drosophila larval neuromuscular junction.
Macleod GT. Cold Spring Harb Protoc. 2012 Jul;2012(7):797-801.
Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity.
Chouhan AK, Ivannikov MV, Lu Z, Sugimori M, Llinas RR, Macleod GT. J Neurosci. 2012 Jan;32(4):1233-43.
Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease.
Rawson JM, Kreko T, Davison H, Mahoney R, Bokov A, Chang L, Gelfond J, Macleod GT, Eaton BA. Aging Cell. 2012 Jun;11(3):418-27.
Differential control of presynaptic CaMKII activation and translocation to active zones.
Shakiryanova D, Morimoto T, Zhou C, Chouhan AK, Sigrist SJ, Nose A, Macleod GT, Deitcher DL, Levitan ES. J Neurosci. 2011 Jun;31(25):9093-100.
Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.
George AA, Macleod GT, Zakon HH. J Neurophysiol. 2011 Jul;106(1):319-31.
Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ. Chouhan AK, Zhang J, Zinsmaier KE, Macleod GT. J Neurosci. 2010 Feb;30(5):1869-81.
Mitochondria: enigmatic stewards of the synaptic vesicle reserve pool.
Ivannikov MV, Harris KM, Macleod GT. Front Synaptic Neurosci. 2010 Oct;2:145.
Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport.
Russo GJ, Louie K, Wellington A, Macleod GT, Hu F, Panchumarthi S, Zinsmaier KE. J Neurosci. 2009 Apr;29(17):5443-55.
Loading Drosophila nerve terminals with calcium indicators.
Rossano AJ, Macleod GT. J Vis Exp. 2007;(6):250.
Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.
Lagow RD, Bao H, Cohen EN, Daniels RW, Zuzek A, Williams WH, Macleod GT, Sutton RB, Zhang B. PLoS Biol. 2007 Apr;5(4):e72.
Synaptic homeostasis on the fast track.
Macleod GT, Zinsmaier KE. Neuron. 2006 Nov;52(4):569-71.
The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation.
Macleod GT, Chen L, Karunanithi S, Peloquin JB, Atwood HL, McRory JE, Zamponi GW, Charlton MP. Eur J Neurosci. 2006 Jun;23(12):3230-44.
The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.
Guo X, Macleod GT, Wellington A, Hu F, Panchumarthi S, Schoenfield M, Marin L, Charlton MP, Atwood HL, Zinsmaier KE. Neuron. 2005 Aug;47(3):379-93.
AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis.
Bao H, Daniels RW, MacLeod GT, Charlton MP, Atwood HL, Zhang B. J Neurophysiol. 2005 Sep;94(3):1888-903.
Genetic analysis of soluble N-ethylmaleimide-sensitive factor attachment protein function in Drosophila reveals positive and negative secretory roles.
Babcock M, Macleod GT, Leither J, Pallanck L. J Neurosci. 2004 Apr;24(16):3964-73.
Synaptic vesicles: test for a role in presynaptic calcium regulation.
Macleod GT, Marin L, Charlton MP, Atwood HL. J Neurosci. 2004 Mar;24(10):2496-505.
Single neuron activity in the Drosophila larval CNS detected with calcium indicators.
Macleod GT, Suster ML, Charlton MP, Atwood HL. J Neurosci Methods. 2003 Aug;127(2):167-78.
Fast calcium signals in Drosophila motor neuron terminals.
Macleod GT, Hegström-Wojtowicz M, Charlton MP, Atwood HL. J Neurophysiol. 2002 Nov;88(5):2659-63.
Formation and function of synapses with respect to Schwann cells at the end of motor nerve terminal branches on mature amphibian (Bufo marinus) muscle.
Macleod GT, Dickens PA, Bennett MR. J Neurosci. 2001 Apr;21(7):2380-92.
Quantal potential fields around individual active zones of amphibian motor-nerve terminals.
Bennett MR, Farnell L, Gibson WG, Macleod GT, Dickens P. Biophys J. 2000 Mar;78(3):1106-18.
Vesicle-associated proteins and quantal release at single active zones of amphibian (Bufo marinus) motor-nerve terminals.
Macleod GT, Gan J, Bennett MR. J Neurophysiol. 1999 Sep;82(3):1133-46.
Quantal secretion and nerve-terminal cable properties at neuromuscular junctions in an amphibian (Bufo marinus).
Macleod GT, Farnell L, Gibson WG, Bennett MR. J Neurophysiol. 1999 Mar;81(3):1135-46.
Probability of quantal secretion and the mobilization of vesicles at the active zones of endplates.
Macleod GT, Khurana V, Gibson WG, Bennett MR. J Theor Biol. 1998 Apr 7;191(3):323-34.
Calcium dependence of quantal secretion from visualized sympathetic nerve varicosities on the mouse vas deferens.
Macleod GT, Lavidis NA, Bennett MR. J Physiol. 1994 Oct 1;480 ( Pt 1)(Pt 1):61-70.
